Centro della Microcitemia e delle Anemia Congenite - Ematologia, Ospedale Galliera, Genoa, Italy. Department of Paediatrics and Orthopaedics, Second University of Naples, Naples, Italy. Department of Gerontology and Muscloskeletal Sciences, Ospedale Galliera, Genoa, Italy. Division of Haematology, Presidio Ospedaliero A. Perrino, Brindisi, Italy. UO Ematologia con Talassemia, Ospedali Villa Sofia-V.Cervello, Palermo, Italy. Fondazione IRCCS 'Ca Granda', Ospedale Maggiore Policlinico, Università di Milano, Milan, Italy. Centro Microcitemia, Ospedale 'Bianchi Melacrino Morelli', Reggio Calabria, Italy. Department of Clinical and Experimental Medicine, University of Ferrara, Arcispedale Sant'Anna, Ferrara, Italy. UOS Talassemia Pediatrica ed Emoglobinopatie Pediatriche, Azienda Ospedaliera 'Antonio Cardarelli', Naples, Italy.